FAK family kinases: The Yin and Yang of cancer cell invasiveness

被引：10
作者：
Genna, Alessandro [1 ]
Gil-Henn, Hava [1 ]
机构：
[1] Bar Ilan Univ, Azrieli Fac Med, 8th Henrietta Szold St,POB 1589, IL-1311502 Safed, Israel
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 04期
基金：
以色列科学基金会;
关键词：
FAK; Pyk2; focal adhesions; invadopodia; invasion; migration;
D O I：
10.1080/23723556.2018.1449584
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Proline-rich tyrosine kinase 2 (PYK2, also known as Pyk2) and its closely related focal adhesion kinase (FAK) modulate cancer cell invasion by coordinating the balance between focal adhesion-mediated migration and invadopodia-dependent extracellular matrix invasion. Our recent findings present Pyk2 and FAK as novel mediators of breast cancer invasiveness and as potential targets for blocking breast cancer metastasis.
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页数：3
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