STUDIES ON SYNTHESES OF HETEROCYCLIC COMPOUNDS .281. SYNTHESIS OF HOMOPROTOBERBERINE-TYPE COMPOUNDS BY PHENOLIC CYCLISATION

被引：24

作者：

KAMETANI, T

TERUI, T

OGINO, T

FUKUMOTO, K

机构：

[1] Pharmaceutical Institute, School of Medicine, Tohoku University, Sendai, No. 85, Kitayobancho

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 06期

关键词：

D O I：

10.1039/j39690000874

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The phenolic cyclisation of 1,2,3,4-tetrahydro-1-(3-hydroxy-4- methoxyphenethyl)-6,7-dimethoxyisoquinoline (VI) gave the homoprotoberberine- type compound (VII), in which cyclisation had taken place at the ortho-position to the hydroxy-group. The suggested structure for the compound, (VII), was assigned from spectroscopic results ; the synthesis of the compound supported the suggested structure. A Mannich reaction of (VI) however, afforded a normal reaction product, homoprotoberberine (XV).

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页码：874 / &

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