AN ASYMMETRIC-SYNTHESIS OF (-)-CARBOVIR

被引：76

作者：

ASAMI, M

TAKAHASHI, J

INOUE, S

机构：

[1] Department of Synthetic Chemistry, Faculty of Engineering, Yokohama National University, Hodogaya-ku, Yokohama, 240, Tokiwadai

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 09期

关键词：

D O I：

10.1016/0957-4166(94)80072-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantioselective deprotonation of trans-4-t-butyldimethylsiloxymethyl-1,2-epoxycyclopentane (trans-4) by a chiral lithium amide, lithium (S)-2-(pyrrolidin-1-ylmethyl)pyrrolidide (1), afforded (1S,4S)-trans-4-t-butyldimethylsiloxymethyl-2-cyclopenten-1-ol (trans-7) in 83 %ee. Alcohol trans-7 was easily transformed to (-)-carbovir, an anti-HIV carbocyclic nucleoside.

引用

页码：1649 / 1652

页数：4

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