PRESENCE OF GELATINASE A AND METALLOELASTASE TYPE PROTEASE AT THE PLASMA-MEMBRANE OF HUMAN SKIN FIBROBLASTS - INFLUENCE OF CYTOKINES AND GROWTH-FACTORS ON CELL-ASSOCIATED METALLOENDOPEPTIDASE LEVELS

被引：31
作者：
BERANGER, JY
GODEAU, G
FRANCES, C
ROBERT, L
HORNEBECK, W
机构：
[1] UNIV PARIS 12,FAC MED,BIOL TISSU CONJONCT LAB,CNRS,ER 74,F-94010 CRETEIL,FRANCE
[2] HOP LA PITIE SALPETRIERE,SERV MED INTERNE,F-75651 PARIS,FRANCE
来源：
CELL BIOLOGY INTERNATIONAL | 1994年 / 18卷 / 07期
关键词：
FIBROBLASTS; ELASTASE-TYPE PROTEASE; GELATINASE A; MATRIX METALLOPROTEINASE; INTERLEUKINS;
D O I：
10.1006/cbir.1994.1100
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Gelatinase A and elastase type proteinase (Homsy, et al, 1988) present at plasma membranes of human skin fibroblasts (HSF) were separated by anion exchange chromatography on a DEAE Tris acryl M column. Elastase type proteinase (HSFE(1)) was able to convert 72 kDa progelatinase A to a lower 66 kDa M.W. active enzyme. Several cytokines (IL-1 beta, IL4, IL6), interferon gamma (IFN gamma) and tumor growth factor beta (TGF-beta) were studied for their ability to modify the levels of those plasma membrane associated proteinases. Among these mediators, only IL-1 beta was found to enhance the amounts of HSF membrane-bound HSFE(1) and Gelatinase A.
引用
收藏
页码：715 / 722
页数：8
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