PROTEIN-C AND PROTEIN-S LEVELS IN UREMIC PATIENTS BEFORE AND AFTER DIALYSIS

被引：5

作者：

DEMICHELI, M ^{[1
]}

CONTINO, L ^{[1
]}

IBERTI, M ^{[1
]}

ORTENSIA, A ^{[1
]}

FINOTTO, E ^{[1
]}

LOMBARDI, A ^{[1
]}

PREDA, L ^{[1
]}

机构：

[1] RES & DEV INSTRUMENTAT LAB SPA,MILAN,ITALY

来源：

THROMBOSIS RESEARCH | 1992年 / 68卷 / 06期

关键词：

PROTEIN-C; PROTEIN-S; UREMIA; DIALYSIS; THROMBOPHILIA;

D O I：

10.1016/0049-3848(92)90057-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The inhibitory capacity of the natural protein C (PC)/protein S (PS) system was evaluated measuring both the functional activity and the antigen level of both these inhibitors in 30 uremic patients before and after a dialytic treatment and in 30 healthy normal volunteers. PC functional activity was determined by two methods, one clotting and one chromogenic. PS antigen level was measured both as free protein and as total content. Unlike previous authors, we found that PC functional activity and the antigen level were normal in patients before dialysis, with a significant increase after. PS functional activity and free and total antigen levels were all normal before dialysis, and all except free antigen showed a significant post-treatment rise.

引用

页码：451 / 457

页数：7

共 13 条

[1]

BERTINA RM, 1984, THROMB HAEMOSTASIS, V48, P1

[2]

BRUMER BM, 1986, KIDNEY, V1

[3] FAMILIAL PROTEIN S DEFICIENCY IS ASSOCIATED WITH RECURRENT THROMBOSIS [J].