PREPARATION AND EVALUATION OF THE ANTIAGGREGATING AND VASODILATING ACTIVITIES OF THE NOVEL 3-NITRO-4(3H)-QUINAZOLINONE DERIVATIVES

被引：5
|
作者：
ITO, S
ANDO, S
YAMAGUCHI, K
FUNAYAMA, N
YAMAMOTO, T
KUROIWA, Y
KUBOTA, T
KOMODA, Y
机构：
[1] HORIUCHI ITARO CO LTD,DEPT RES & DEV,TOKYO 189,JAPAN
[2] SHOWA UNIV,SCH PHARMACEUT SCI,SHINJUKU KU,TOKYO 142,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(01)81239-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The structures of the novel adducts (9 ), prepared from the reaction between powder of 4(3H)-quinazolinone derivatives (8) and acetyl nitrate at room temperature, were elucidated by chemical modification and spectroscopy. The final structure of 9a (designated as AP3) was confirmed by X-ray crystallography as the 3-nitro-4(3H)-quinazolinone derivative. 9a elevated the cyclic GMP level in cells showing antiaggregating activities and had a relaxing effect on rabbit vascular smooth muscle in a concentration dependent manner in vitro.
引用
收藏
页码：611 / 614
页数：4
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