IN-VIVO P-31 NMR MEASUREMENT OF GLUCOSE-6-PHOSPHATE IN THE RAT MUSCLE AFTER EXERCISE

被引：38

作者：

BLOCH, G

CHASE, JR

AVISON, MJ

SHULMAN, RG

机构：

[1] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,333 CEDAR ST,POB 3333,NEW HAVEN,CT 06510

[2] YALE UNIV,DEPT INTERNAL MED,NEW HAVEN,CT 06510

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 30卷 / 03期

关键词：

GLYCOGEN; GASTROCNEMIUS; GLYCOGEN SYNTHESIS;

D O I：

10.1002/mrm.1910300311

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Comparison of P-31 NMR spectra of the rat gastrocnemius, obtained in vivo and from PCA extracts, after electrically induced contractions, demonstrates that glucose-6-phosphate (G6P) is the major metabolite in the low-field part of the PME spectral region. In vivo P-31 NMR can thus be used to measure the muscle G6P concentration after exercise.

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页码：347 / 350

页数：4

相关论文

共 12 条

[1]

BARANY M, 1982, METHOD ENZYMOL, V85, P624

[2] BIOENERGETIC CHANGES DURING CONTRACTION AND RECOVERY IN DIABETIC RAT SKELETAL-MUSCLE [J].

CHALLISS, RAJ ;

VRANIC, M ;

RADDA, GK .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (01) :E129-E137

[3]

GADIAN DG, 1979, BIOL APPLICATIONS MA, P463

[4]

LERUMEUR E, 1988, 7TH P ANN M SOC MAGN, P94

[5] INVITRO P-31-NMR SPECTROSCOPIC STUDIES OF RAT-LIVER SUBJECTED TO CHRONIC ETHANOL ADMINISTRATION [J].

LING, MF ;

BRAUER, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1051 (02) :151-158

[6] DIFFERENCES IN AMMONIA AND ADENYLATE METABOLISM IN CONTRACTING FAST AND SLOW MUSCLE [J].

MEYER, RA ;

TERJUNG, RL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 237 (03) :C111-C118

[7]

PAN JW, 1989, 8TH SOC MAGN RES MED, P541

[8] IN VIVO REGULATION OF RAT MUSCLE GLYCOGEN SYNTHETASE ACTIVITY [J].

PIRAS, R ;

STANELONI, R .

BIOCHEMISTRY, 1969, 8 (05) :2153-+

[9] RELATIVE CONTRIBUTION OF GLYCOGEN-SYNTHESIS AND GLYCOLYSIS TO INSULIN-MEDIATED GLUCOSE-UPTAKE - A DOSE-RESPONSE EUGLYCEMIC CLAMP STUDY IN NORMAL AND DIABETIC RATS [J].

ROSSETTI, L ;

GIACCARI, A .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (06) :1785-1792

[10] P-31 NUCLEAR-MAGNETIC-RESONANCE MEASUREMENTS OF MUSCLE GLUCOSE-6-PHOSPHATE - EVIDENCE FOR REDUCED INSULIN-DEPENDENT MUSCLE GLUCOSE-TRANSPORT OR PHOSPHORYLATION ACTIVITY IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].

ROTHMAN, DL ;

SHULMAN, RG ;

SHULMAN, GI .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (04) :1069-1075