ASSOCIATION OF POOR CLINICAL STATUS AND HEAVY EXPOSURE TO TOBACCO-SMOKE IN PATIENTS WITH CYSTIC-FIBROSIS WHO ARE HOMOZYGOUS FOR THE F508 DELETION

被引：60

作者：

CAMPBELL, PW

PARKER, RA

ROBERTS, BT

KRISHNAMANI, MRS

PHILLIPS, JA

机构：

[1] VANDERBILT UNIV, SCH MED, DEPT PEDIAT, DIV PULM MED, NASHVILLE, TN 37232 USA

[2] VANDERBILT UNIV, SCH MED, DEPT PEDIAT, DIV GENET, NASHVILLE, TN 37232 USA

[3] VANDERBILT UNIV, SCH MED, DEPT PREVENT MED, NASHVILLE, TN 37232 USA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 120卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(05)80438-X

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We examined the association between clinical status and exposure to tobacco smoke in 44 patients homozygous for the F508 cystic fibrosis mutation. Heavy exposure to tobacco smoke was significantly associated with lower Shwachman scores, poorer results of pulmonary function tests, and a fivefold increase in the number of pulmonary-related hospitalizations during the previous year.

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页码：261 / 264

页数：4

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