CONFORMATIONAL COUPLING BETWEEN STRUCTURAL UNITS - DECISIVE STEP IN THE FORMATION OF THE FUNCTIONAL STRUCTURE OF PROTEINS

被引：0

作者：

GHELIS, C

YON, JM

机构：

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COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D | 1979年 / 289卷 / 02期

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中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Proteins built up of several structural domains are compared with oligomeric proteins made up of several subunits. On this basis the functional consequences of a conformational coupling between domains are analyzed. From the data obtained on the elastase molecule it is proposed that the last step in protein folding insures the optimal coupling between domains and the energy of interaction is utilized for catalysis.

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页码：197 / 199

页数：3

相关论文

共 15 条

[1] STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN .5. ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 A RESOLUTION [J].

BIRKTOFT, JJ ;

BLOW, DM .

JOURNAL OF MOLECULAR BIOLOGY, 1972, 68 (02) :187-&

[2] NATURE OF ACCESSIBLE AND BURIED SURFACES IN PROTEINS [J].

CHOTHIA, C .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 105 (01) :1-14

[3] BINDING INTERACTIONS BETWEEN 2 LIGANDS AND A MONOMERIC PROTEIN . STUDY ON INDOLE, PROTONS AND CHYMOTRYPSIN [J].

GAREL, JR ;

LABOUESSE, B .

JOURNAL OF MOLECULAR BIOLOGY, 1970, 47 (01) :41-+

[4] CATALYSIS BY CHYMOTRYPSINOGEN - DEMONSTRATION OF AN ACYL-ZYMOGEN INTERMEDIATE [J].

GERTLER, A ;

WALSH, KA ;

NEURATH, H .

BIOCHEMISTRY, 1974, 13 (06) :1302-1310

[5] FOLDING OF PANCREATIC ELASTASE - INDEPENDENT DOMAIN REFOLDING AND INTER-DOMAIN INTERACTION [J].

GHELIS, C ;

TEMPETEGAILLOURDET, M ;

YON, JM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 84 (01) :31-36

[6]

HODGBERGRAIBAUD A, 1977, BIOCHEMISTRY-US, V16, P4014

[7] STRUCTURAL PATTERNS IN GLOBULAR PROTEINS [J].

LEVITT, M ;

CHOTHIA, C .

NATURE, 1976, 261 (5561) :552-558

[8] ON NATURE OF ALLOSTERIC TRANSITIONS - A PLAUSIBLE MODEL [J].

MONOD, J ;

WYMAN, J ;

CHANGEUX, JP .

JOURNAL OF MOLECULAR BIOLOGY, 1965, 12 (01) :88-&

[9] COMPARISON OF SUPER-SECONDARY STRUCTURES IN PROTEINS [J].

RAO, ST ;

ROSSMANN, MG .

JOURNAL OF MOLECULAR BIOLOGY, 1973, 76 (02) :241-+

[10] EXPLORING STRUCTURAL HOMOLOGY OF PROTEINS [J].

ROSSMANN, MG ;

ARGOS, P .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 105 (01) :75-95