HUMAN INTERLEUKIN-2 RECEPTOR BETA-CHAIN GENE - CHROMOSOMAL LOCALIZATION AND IDENTIFICATION OF 5' REGULATORY SEQUENCES

被引：75
作者：
GNARRA, JR [1 ]
OTANI, H [1 ]
WANG, MG [1 ]
MCBRIDE, OW [1 ]
SHARON, M [1 ]
LEONARD, WJ [1 ]
机构：
[1] NCI,DIV CANC BIOL & DIAGNOSIS,BIOCHEM LAB,BETHESDA,MD 20892
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 09期
关键词：
promoter; Z-DNA;
D O I：
10.1073/pnas.87.9.3440
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2Rα chain and the 70-kDa IL-2Rβ chain. The low-affinity, IL-2Rα chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2Rβ receptor. We report here identification of the genomic locus for IL-2Rβ. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5'-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT)(n) class of middle repetitive elements, which may play an interesting regulatory role. The IL-2Rβ gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.
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页码：3440 / 3444
页数：5
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