Comparative Study of the Efficacy of Different Regimens of Triple Therapy for Treatment of Egyptian Patients with Gastric and Duodenal Ulcer Due To Helicobacter Pylori

Helicobacter pylori (H. Pylori) is associated with over 90% duodenal ulcer, 80% gastric ulcer, mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma So its eradication success could cure this diseases and prevent its complications. This study was performed to compare the efficacy of different regimens of triple therapy for treatment of gastric ulcer and duodenal ulcer due to HP. 100 Consecutive H. pyloriinfected subjects were randomly assigned to 6 groups as follow: Group (A) included 18 patients and received omeprazole 20 mg,tinidazole 500 mg and clarithromycin 250 mg twice daily for 7 days(O20T500C250-7d/n=18).Group (B) included 18 patients and received the same regimen used in group A for 14 days (O20T500C250-14d/n=18). Group (C) included 15 patients and received omeprazole 20 mg, tinidazole 500 mg and doxycycline 50 mg twice daily for 7 days(O20T500D50-7d/n=15). Group (D) included 15 patients and received the same regimen used in group C for 14 days(O20T500D50-14d/n=15). Group (E) included 17 patents and received esomeprazole 20 mg, amoxycillin 1gm and clarithromycin 500 mg twice daily for 7 days(E(20)A(1gm)C(500)- 7d/n=17). Group (F) included 15 patients and received the same regimen used in group E for 14 days(E(20)A(1gm)C(500)- 14d/n=17). H. Pylori eradication was confirmed by histopathological examination and biopsy urease test (CLO test) at least 8 weeks after cessation of therapy. Results: H. Pylori eradication rates were as follow Group (A) 66.66%, Group (B)72.2%, Group (C) 53.3%, Group (D) 60%, Group (E) 88.23%andGroup (F) 100%. Conclusion: (E(20)A(1gm)C(500)-14d) is the highest active regimen for the eradication of h. pylori.