One pot synthesis of 3, 4-dihydropyrimidin-2(1H) - ones catalyzed by aluminium sulphate: An improved procedure for the Biginelli reaction

被引：0
作者：
Khairnar, B. J. [1 ]
Kapade, R. J. [1 ]
Borse, K. M. [1 ]
Chaudhari, B. R. [1 ]
机构：
[1] JETs Zulal Bhilajirao Patil Coll, Dept Chem, Dhule 424002, India
来源：
ORIENTAL JOURNAL OF CHEMISTRY | 2010年 / 26卷 / 02期
关键词：
Biginelli reaction; 3; 4-dihydropyrimidin-2(1H)-ones; Aluminium sulphate; Condensation reaction; multicomponent reaction;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple effective synthesis of 3, 4-dihydropyrimidin-2(1H)-one/thione derivatives using Aluminium sulphate (Al-2(SO4)(3)center dot 18H(2)O) catalyst from aromatic aldehydes, 1, 3-dicarbonyl compounds & (thio) urea in glacial acetic acid is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yield and short reaction time.
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页码：655 / 660
页数：6
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