ACID SECRETION IN GUINEA PIGS WITH CHRONIC GASTRIC FISTULAS

被引：9

作者：

RAGINS, H

WINCZE, F

机构：

[1] Gastrointestinal Research Unit, Department of Surgery, Albert Einstein College of Medicine, Bronx

来源：

JOURNAL OF SURGICAL RESEARCH | 1969年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0022-4804(69)90056-0

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Chronic gastric fistula guinea pigs have survived and functioned well for more than 9 months. The cannula construction, surgical technique, and the method of gastric juice collection are described in detail. Basal hourly volumes generally ranged from 0-5 ml. and rarely approached 10 ml. and the free acid ranged up to 90 mEq./liter. Stimulated hourly volumes ranged up to 16 ml. and the free acid concentration to 127 mEq./liter. Dose-response curves for subcutaneous Histalog showed a leveling off at a range of 5.44-8.16 mg./kg./hour. Continuous maximal stimulation of acid secretion in the unanesthetized unrestrained guinea pig was achieved by cementing an electrolytic microflow pump to the shaved back of the animal. © 1969.

引用

页码：217 / &