ENZYME REPLACEMENT THERAPY IN GAUCHERS-DISEASE - PRELIMINARY CLINICAL-TRIAL OF A NEW ENZYME PREPARATION

被引：106

作者：

BEUTLER, E ^{[1
]}

DALE, GL ^{[1
]}

GUINTO, E ^{[1
]}

KUHL, W ^{[1
]}

机构：

[1] CITY HOPE NATL MED CTR,DEPT HEMATOL,DUARTE,CA 91010

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1977年 / 74卷 / 10期

关键词：

D O I：

10.1073/pnas.74.10.4620

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：4620 / 4623

页数：4

共 16 条

[1]

BEUTLER E, 1977, NEW ENGL J MED, V296, P942

[2] ACID-HYDROLASES IN LEUKOCYTES AND PLATELETS OF NORMAL SUBJECTS AND IN PATIENTS WITH GAUCHERS AND FABRYS-DISEASE [J].

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KUHL, W ;

MATSUMOTO, F ;

PANGALIS, G .

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[3]

BEUTLER E, 1976, J LAB CLIN MED, V88, P328

[4] HEPATOSPLENOMEGALY, ABDOMINAL PAIN, ANEMIA, AND BONE LESIONS [J].

BEUTLER, E ;

SOUTHGAT.MT .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1973, 224 (04) :502-510

[5]

Brady R O, 1976, Adv Exp Med Biol, V68, P523

[6] REPLACEMENT THERAPY FOR INHERITED ENZYME DEFICIENCY - USE OF PURIFIED GLUCOCEREBROSIDASE IN GAUCHERS-DISEASE [J].

BRADY, RO ;

PENTCHEV, PG ;

GAL, AE ;

HIBBERT, SR ;

DEKABAN, AS .

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[7] SPHINGOLIPIDOSES [J].

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[8] IN-VITRO CORRECTION OF DEFICIENT HUMAN FIBROBLASTS BY BETA-GLUCURONIDASE FROM DIFFERENT HUMAN SOURCES [J].

BROT, FE ;

GLASER, JH ;

ROOZEN, KJ ;

SLY, WS .

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[9]

COOLEY CM, 1976, BIOCHIM BIOPHYS ACTA, V451, P417

[10] SOLUBILIZATION OF GLUCOCEREBROSIDASE FROM HUMAN PLACENTA AND DEMONSTRATION OF A PHOSPHOLIPID REQUIREMENT FOR ITS CATALYTIC ACTIVITY [J].

DALE, GL ;

VILLACORTE, DG ;

BEUTLER, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 71 (04) :1048-1053

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