HISTOMORPHOLOGICAL EFFECTS OF CISPLATIN ON KIDNEY OF MALE WISTAR ALBINO RATS

Cancer is the most dreaded disease and currently taking a heaviest toll of human lives. The number of cancer patients diagnosed is growing at an alarming proportion. So, its treatment forms an important part of modern health care. Cisplatin is one of the important anticancer drugs used to treat a number of cancers like that of head and neck, prostate, breast, cervix, uterus etc. Though comparatively a safe drug it has got many side effects amongst which nephrotoxicity is of common occurance. Hence, a study was conducted, in the Department of Anatomy Government Medical College Jammu, on 40 male albino Wistar rats, obtained from the Animal house of Department of Pharmacology Government Medical College Jammu, to determine the toxic effects of Cisplatin on kidney of rats. The rats were divided into 4 groups where 3 groups were given the test drug Cisplatin I. P. (Intraperitoneally) in doses of 0.2mg/kg body weight for 7 days, 1 mg/kg body weight for 7 days and 45 mg/kg body weight as a single dose respectively, whereas in the 4th group or control group normal saline of same volume was injected I. P. These rats were subsequently anaesthetised, dissected and their kidneys were taken out. The kidneys were then subjected to standard histological slide preparation by paraffin embedding method and longitudinal and transverse sections so prepared were stained by H &E stain and observed under a light microscope. In group I (Control group) no macroscopic as well as microscopic changes were seen in the kidneys. In group II, III, IV, well-marked microscopic changes were seen in the kidneys.