THE ROLE OF 5-HT1A SEROTONIN AND D-2 DOPAMINE-RECEPTORS IN BUSPIRONE EFFECTS ON CORTICAL ELECTRICAL-ACTIVITY IN RATS

被引：9

作者：

BOGDANOV, NN ^{[1
]}

BOGDANOV, MB ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI, CARDIOL RES CTR, INST EXPTL CARDIOL, MOSCOW 121552, RUSSIA

来源：

NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期

关键词：

EEG; RAT; BUSPIRONE; RACLOPRIDE; 8-OH-DPAT; 5-HT1A RECEPTOR; D-2; RECEPTOR;

D O I：

10.1016/0304-3940(94)90030-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of buspirone (5 and 10 mg/kg i.p.), 8-OH-DPAT (0.25 mg/kg) and raclopride (2.5 mg/kg) on the EEG power spectra of the sensorimotor cortex were studied in freely moving rats. Buspirone (5 mg/kg) and 8-OH-DPAT produced selective slowing of the theta-activity. Buspirone (10 mg/kg) produced slowing of the theta-activity and increased the power of the alpha-band (9-11 Hz). Raclopride alone did not influence EEG power spectra. Simultaneous injection of 8-OH-DPAT and raclopride produced marked slowing of the theta-activity and increased the power of the alpha-band. The role of 5 HT1A and D-2 dopamine receptors in buspirone effects on cortical electrical activity in rats was discussed.

引用

页码：1 / 4

页数：4

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