THE SPEED OF CORNEAL EPITHELIAL WOUND-HEALING

被引：12
|
作者：
DALE, PD
SHERRATT, JA
MAINI, PK
机构：
[1] Centre for Mathematical Biology, Mathematical Institute 24-29, Oxford, OX1 3LB, St. Giles'
[2] Nonlinear Systems Laboratory, Mathematics Institute University of Warwick, Coventry
来源：
APPLIED MATHEMATICS LETTERS | 1994年 / 7卷 / 02期
关键词：
TRAVELING WAVES; EPIDERMAL GROWTH FACTOR; REACTION DIFFUSION; MITOSIS MIGRATION;
D O I：
10.1016/0893-9659(94)90022-1
中图分类号：
O29 [应用数学];
学科分类号：
070104 ;
摘要：
We propose a reaction-diffusion model of the mechanisms involved in the healing of corneal surface wounds. The model focuses on the stimulus for increased mitotic and migratory activity, specifically the role of epidermal growth factor. We determine an analytic approximation for the speed of travelling wave solutions of the model and verify the result numerically. The predicted speed compares very well with experimentally measured healing rates.
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页码：11 / 14
页数：4
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