PROTECTION OF IMMUNOSUPPRESSED MICE AGAINST TRANSLOCATION OF PSEUDOMONAS-AERUGINOSA FROM THE GUT BY ORAL IMMUNIZATION WITH RECOMBINANT PSEUDOMONAS-AERUGINOSA OUTER-MEMBRANE PROTEIN-I EXPRESSING SALMONELLA-DUBLIN

被引：15
|
作者：
TOTH, A
SCHODEL, F
DUCHENE, M
MASSARRAT, K
BLUM, B
SCHMITT, A
DOMDEY, H
VONSPECHT, BU
机构：
[1] UNIV FREIBURG, CHIRURG KLIN, D-79106 FREIBURG, GERMANY
[2] MAX PLANCK INST BIOCHEM, D-82152 MARTINSRIED, GERMANY
[3] UNIV MUNICH, GENZENTRUM, MOLEK BIOL LAB, D-82152 MARTINSRIED, GERMANY
来源：
VACCINE | 1994年 / 12卷 / 13期
关键词：
PSEUDOMONAS AERUGINOSA; OUTER MEMBRANE PROTEIN; SALMONELLA DUBLIN;
D O I：
10.1016/0264-410X(94)90246-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
AroA Salmonella dublin was used as recipient for a plasmid coding for the outer membrane protein I (OprI) of Pseudomonas aeruginosa. Oral immunization of Balb/c mice with recombinant S. dublin induced serum IgG and IgA antibodies against P. aeruginosa. In spleen and Peyer's patches anti-P. aeruginosa IgG- and IgA-secreting cells could be measured by the ELISPOT technique. In an oral challenge of immunosuppressed mice with P. aeruginosa the orally immunized animals had a 58-fold higher LD(50) than control animals.
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页码：1215 / 1221
页数：7
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