ACTIVE-TRANSPORT OF BENZO[A]PYRENE IN APICAL MEMBRANE-VESICLES FROM NORMAL HUMAN INTESTINAL EPITHELIUM

被引：34
作者：
PENNY, JI
CAMPBELL, FC
机构：
[1] NINEWELLS HOSP,DEPT SURG,DUNDEE DD1 9SY,SCOTLAND
[2] UNIV DUNDEE,SCH MED,DUNDEE DD1 9SY,SCOTLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1994年 / 1226卷 / 02期
关键词：
BENZO[A]PYRENE; INTESTINE (HUMAN); CARCINOGEN; TRANSPORT; P-GLYCOPROTEIN;
D O I：
10.1016/0925-4439(94)90034-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transport of the carcinogen benzo[a]pyrene in apical membrane vesicles (AMV) from normal human intestine, was investigated. Benzo[a]pyrene transport was found in AMV throughout the small intestine, but was greatest in colon. Evidence suggesting involvement of P-Glycoprotein (P-Gp), included (1) comparable transport of P-Gp substrate doxorubicin, (2) transport stimulation by ATP and (3) transport suppression by the P-Gp inhibitor, verapamil.
引用
收藏
页码：232 / 236
页数：5
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