COMPARISON OF PROPAFENONE TO ATENOLOL FOR THE PROPHYLAXIS OF POSTCARDIOTOMY SUPRAVENTRICULAR TACHYARRHYTHMIAS - A PROSPECTIVE TRIAL

被引：27

作者：

MERRICK, AF

ODOM, NJ

KEENAN, DJM

GROTTE, GJ

机构：

[1] Department of Cardiothoracic Surgery, Manchester Royal Infirmary, Manchester, M 15 9AW, Oxford Road

[2] Transplantation Biology Unit, Division of Cell and Molecular Biology, Institute of Child Health, London, WCIN 1EH

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1995年 / 9卷 / 03期

关键词：

PROPAFENONE; SUPRAVENTRICULAR TACHYARRHYTHMIA; CARDIAC SURGERY;

D O I：

10.1016/S1010-7940(05)80062-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To compare the efficacy of propafenone to atenolol in the prevention of supraventricular tachyarrhythmias (SVT) following cardiac surgery, 207 consecutive patients were randomly allocated to receive either propafenone 300 mg twice daily (105 patients) or atenolol 50 mg once daily (102 patients) orally for 7 days after operation. Double blinding was achieved using placebos. The end point was the development of a SVT which was symptomatic, recurrent, or lasting over 2 minutes, or the occurrence of adverse effects possibly attributable to the drugs. The groups were well matched for age, sex, bypass- and cross-clamp times, and other data. Thirteen patients in the propafenone group and 11 in the atenolol group developed SVT during the first week after operation, (P=0.89, non significant, chi-squared with Yates' correction.) In our study propafenone and atenolol were of approximately equal efficacy in preventing post cardiotomy SVT. Propafenone may have an advantage in being less negatively inotropic than atenolol; it could therefore be used in patients with poor left ventricular function or marginal haemodynamics when a beta blocker is contraindicated.

引用

页码：146 / 149

页数：4

共 29 条

[21]

Mills S.A., Poole G.V., Breyer R.H., Holliday R.H., Lavender S.W., Blanton K.R., Hudspeth A.S., Johnston F.R., Cordell A.R., Digoxin and propranolol in the prophylaxis of dysrhythmias after coronary artery bypass grafting, Circulation, 68, pp. 222-225, (1983)

[22]

Mohr B., Smolinsky B., Goor D.A., Prevention of supraventricular tachyarrhythmia with low dose propranolol after coronary bypass, J Thorac Cardiovasc Surg, 81, pp. 840-845, (1981)

[23]

Ormerod D., Mc Gregor C., Stone D.L., Wisbey C., Petch M.C., Arrhythmias after coronary bypass surgery, Br Heart J, 51, pp. 618-621, (1984)

[24]

Roffman J.A., Fieldman A., Digoxin and propranolol in the prophylaxis of supraventricular tachydysrhythmias after coronary artery bypass surgery, Ann Thorac Surg, 31, pp. 496-501, (1981)

[25]

Silverman N.A., Wright R., Levitsky S., Efficacy of low dose propranolol in preventing postoperative supraventricular tachyarrhythmias, Ann Surg, 196, pp. 194-197, (1982)

[26]

Stanton M.S., Prystowsky E.N., Fineberg N.S., Miles W.M., Zipes D.P., Heger J.J., Incidence of ventricular tachycardia or ventricular fibrillation as pro-arrhythmic effect during drug treatment of ventricular arrhythmia (Abstract), J am Coll Cardiol, 9, (1987)

[27]

Stevenson J.W., Macvaugh H., Tomasello D.N., Josephson M.E., Propranolol for prevention of postoperative cardiac arrhythmias: A randomised study, Ann Thorac Surg, 29, pp. 113-116, (1980)

[28]

Thormann J., Schwarz F., Long term observation of cardiac arrhythmias during and after cardiac surgery, Scand J Thorac Cardiovasc Surg, 10, pp. 31-35, (1976)

[29]

Tyras D.H., Stothert J.C., Kaiser G.C., Barner H.B., Codd J.E., Will-Man V.E., Supraventricular tachyarrhythmias after myocardial revascularisation: A randomised trial of prophylactic digitalisation, J Thorac Cardiovasc Surg, 77, pp. 310-314, (1979)

← 1 2 3 →