ANATOMICAL DISTRIBUTION AND POSTNATAL CHANGES IN ENDOGENOUS FREE D-ASPARTATE AND D-SERINE IN RAT-BRAIN AND PERIPHERY

被引:206
作者
HASHIMOTO, A [1 ]
OKA, T [1 ]
NISHIKAWA, T [1 ]
机构
[1] RES DEV CORP JAPAN,CELL & INFORMAT GRP,PRECURSORY RES EMBRYON SCI & TECHNOL,KAWAGUCHI,SAITAMA 332,JAPAN
关键词
D-AMINO ACID; D-ASPARTATE OXIDASE; D-AMINO ACID OXIDASE; N-METHYL-D-ASPARTATE RECEPTOR;
D O I
10.1111/j.1460-9568.1995.tb00687.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have investigated the anatomical distribution and postnatal development of D-aspartate and D-serine in the rat brain and periphery using HPLC techniques. D-Serine was confined predominantly to. the brain throughout postnatal life. At birth, a substantial quantity of D-serine was observed throughout the brain areas. The cerebral D-serine content increased from birth to postnatal week (PW) 3 and remained constant thereafter, whereas the cerebellar D-serine content peaked at PW1. in contrast, the transient emergence of D-aspartate was found in almost all brain and peripheral organs. A substantial quantity of D-aspartate was also seen in all brain areas at birth, whereas the D-aspartate content in the cerebrum and cerebellum decreased dramatically by PW1 and 7 respectively. Further, the D-aspartate content and the ratio of D-aspartate to total aspartate were highest in the adrenal at PW3 (608 +/- 70 nmol/g, 45.9%) and in the testis at PW14 (221 +/- 7 nmol/g, 57.8%) respectively. Because D-serine potentiates N-methyl-D-aspartate receptor-mediated transmission through the strychnine-insensitive glycine site and because D-serine exhibits an N-methyl-D-aspartate receptor-related distribution and development, D-serine may be a tenable candidate for an intrinsic ligand for the glycine site. In contrast, because the periods of maximal emergence of D-aspartate in the brain and periphery occur during critical periods of morphological and functional maturation of organs, D-aspartate could participate in the regulation of these developmental processes of organs.
引用
收藏
页码:1657 / 1663
页数:7
相关论文
共 57 条
[2]   MITOTIC-ACTIVITY OF ADRENAL MEDULLARY CELLS IN MOUSE AT DIFFERENT AGES AND FOLLOWING UNILATERAL ADRENALECTOMY [J].
BENEDETTI, A .
EXPERIENTIA, 1976, 32 (01) :108-109
[3]   PATTERN OF CELL MIGRATION DURING CORTICAL HISTOGENESIS [J].
BERRY, M ;
EAYRS, JT ;
ROGERS, AW .
NATURE, 1964, 203 (494) :591-&
[4]   QUANTIFICATION OF D-AMINO ACIDS IN HUMAN URINE USING GC-MS AND HPLC [J].
BRUCKNER, H ;
HAASMANN, S ;
FRIEDRICH, A .
AMINO ACIDS, 1994, 6 (02) :205-211
[5]   PRESENCE OF THE N-METHYL-D-ASPARTATE-ASSOCIATED GLYCINE RECEPTOR AGONIST, D-SERINE, IN HUMAN TEMPORAL CORTEX - COMPARISON OF NORMAL, PARKINSON, AND ALZHEIMER TISSUES [J].
CHOUINARD, ML ;
GAITAN, D ;
WOOD, PL .
JOURNAL OF NEUROCHEMISTRY, 1993, 61 (04) :1561-1564
[6]   D-AMINO ACIDS IN ANIMALS [J].
CORRIGAN, JJ .
SCIENCE, 1969, 164 (3876) :142-+
[7]  
DANIELLO A, 1993, J BIOL CHEM, V268, P26941
[8]   PRESENCE OF D-ALANINE IN PROTEINS OF NORMAL AND ALZHEIMER HUMAN BRAIN [J].
DANIELLO, A ;
VETERE, A ;
FISHER, GH ;
CUSANO, G ;
CHAVEZ, M ;
PETRUCELLI, L .
BRAIN RESEARCH, 1992, 592 (1-2) :44-48
[9]   [H-3] D-SERINE LABELS STRYCHNINE-INSENSITIVE GLYCINE RECOGNITION SITES OF RAT CENTRAL NERVOUS-SYSTEM [J].
DANYSZ, W ;
FADDA, E ;
WROBLEWSKI, JT ;
COSTA, E .
LIFE SCIENCES, 1990, 46 (03) :155-164
[10]  
DAVIES LP, 1975, J NEUROCHEM, V25, P299