CONTROL OF SCARRING IN ADULT WOUNDS BY NEUTRALIZING ANTIBODY TO TRANSFORMING GROWTH-FACTOR-BETA

被引：518

作者：

SHAH, M ^{[1
]}

FOREMAN, DM ^{[1
]}

FERGUSON, MWJ ^{[1
]}

机构：

[1] UNIV MANCHESTER, SCH BIOL SCI, DEPT CELL & STRUCT BIOL, STOPFORD BLDG, MANCHESTER M13 9PT, LANCS, ENGLAND

来源：

LANCET | 1992年 / 339卷 / 8787期

关键词：

D O I：

10.1016/0140-6736(92)90009-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adult wounds heal with scar-tissue formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. We injected the margins of healing dermal wounds in adult rats with neutralising antibody (NA) to transforming growth factor-beta (TGF-beta). All control wounds (irrelevant antibody, or TGF-beta, or no injection) healed with scarring, whereas the NA-treated wounds healed without scar-tissue formation; NA-treated wounds had fewer macrophages and blood vessels, lower collagen and fibronectin contents, but identical tensile strength and more normal dermal architecture than the other wounds. Early manipulation of the concentrations of selected cytokines may be a new approach to the control of scarring.

引用

页码：213 / 214

页数：2

共 10 条

[1] SUPPRESSION OF EXPERIMENTAL GLOMERULONEPHRITIS BY ANTISERUM AGAINST TRANSFORMING GROWTH FACTOR-BETA-1 [J].