ISOLATION OF LESS-THAN-GLU-ASN-PHE-HIS-LEU-ARG-PRO-NH2 (ANTHO-RPAMIDE-II), A NOVEL, BIOLOGICALLY-ACTIVE NEUROPEPTIDE FROM SEA-ANEMONES

被引：16
作者：
CARSTENSEN, K
MCFARLANE, ID
RINEHART, KL
HUDMAN, D
SUN, FR
GRIMMELIKHUIJZEN, CJP
机构：
[1] UNIV HAMBURG,CTR MOLEC NEUROBIOL,MARTINISTR 52,W-2000 HAMBURG 20,GERMANY
[2] UNIV HULL,DEPT APPL BIOL,HULL HU6 7RX,N HUMBERSIDE,ENGLAND
[3] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801
来源：
PEPTIDES | 1993年 / 14卷 / 02期
关键词：
NEUROTRANSMITTER; NEUROHORMONE; PEPTIDE STRUCTURE; MASS SPECTROMETRY; COELENTERATE;
D O I：
10.1016/0196-9781(93)90020-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide) we have isolated the neuropeptide <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (Antho-RPamide II) from extracts of the sea anemone Anthopleura elegantissima. Addition of low concentrations of Antho-RPamide II to a tentacle preparation of sea anemones inhibited the spontaneous, rhythmic contractions, suggesting that the peptide is a neurotransmitter or neuromodulator.
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页码：131 / 135
页数：5
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