DEVELOPMENT OF UTERINE ADENOMYOSIS AFTER TREATMENT WITH DOPAMINE ANTAGONISTS IN MICE

被引：35

作者：

SINGTRIPOP, T ^{[1
]}

MORI, T ^{[1
]}

MIN, KP ^{[1
]}

SAKAMOTO, S ^{[1
]}

KAWASHIMA, S ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT ENDOCRINOL,TOKYO 113,JAPAN

来源：

LIFE SCIENCES | 1991年 / 49卷 / 03期

关键词：

D O I：

10.1016/0024-3205(91)90004-U

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Development of uterine adenomyosis was studied in SHN mice treated with psychotherapeutic drugs, sulpiride and perphenazine, and gastroenteric drug, metoclopramide, which act as dopamine antagonists to increase prolactin release from the pituitary gland. Administration of these drugs twice daily for 40-70 or 40-90 days of age induced an elevation in serum level of prolactin. Furthermore, the treated mice showed a prolongation of metestrous plus diestrous phase and a high incidence of uterine adenomyosis compared with vehicle-treated control mice. These results indicate that hyperprolactinemia produced by continuous treatment with psychotherapeutic and gastroenteric drugs is responsible for the occurrence of irregular estrous cycles and the genesis of uterine adenomyosis in mice.

引用

页码：201 / 206

页数：6

共 19 条

[1]

[Anonymous], 1962, NOVAKS GYNECOLOGIC O

[2]

BENAKIS A, 1967, J PHARMACOL-PARIS, V77, P367

[3] PROLACTIN INHIBITS ESTROGEN SYNTHESIS IN THE OVARY [J].

DORRINGTON, J ;

GORELANGTON, RE .

NATURE, 1981, 290 (5807) :600-602

[4]

FORMAN LJ, 1981, P SOC EXP BIOL MED, V167, P354

[5]

HUSBY RA, 1982, AM J OBSTET GYNECOL, V144, P939

[6] ECTOPIC PITUITARY GRAFTS IN MICE - HORMONE LEVELS, EFFECTS ON FERTILITY, AND THE DEVELOPMENT OF ADENOMYOSIS UTERI, PROLACTINOMAS, AND MAMMARY CARCINOMAS [J].

HUSEBY, RA ;

SOARES, MJ ;

TALAMANTES, F .

ENDOCRINOLOGY, 1985, 116 (04) :1440-1448

[7]

HYLKA VW, 1985, LIFE SCI, V37, P51

[8] CONTRASTING EFFECTS OF PROLACTIN ON LUTEAL AND FOLLICULAR STEROIDOGENESIS [J].

KALISON, B ;

WARSHAW, ML ;

GIBORI, G .

JOURNAL OF ENDOCRINOLOGY, 1985, 104 (02) :241-250

[9]

Lacassagne A, 1935, CR SOC BIOL, V120, P1156

[10]

Loeb L, 1936, P SOC EXP BIOL MED, V35, P320

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