EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) ON HUMAN ARTICULAR-CARTILAGE CHONDROCYTES

被引：38

作者：

DAVIES, ME ^{[1
]}

DINGLE, JT ^{[1
]}

PIGOTT, R ^{[1
]}

POWER, C ^{[1
]}

SHARMA, H ^{[1
]}

机构：

[1] BRITISH BIOTECHNOL LTD, OXFORD, ENGLAND

来源：

CONNECTIVE TISSUE RESEARCH | 1991年 / 26卷 / 03期

关键词：

CHONDROCYTES; ARTICULAR CARTILAGE; ICAM-1; ELAM-1; INTERLEUKIN-1;

D O I：

10.3109/03008209109152439

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Monoclonal antibodies have been used to demonstrate the induction of intercellular adhesion molecule 1 (ICAM-1) on chondrocytes in human articular cartilage. ICAM-1 was found not to be constitutively expressed but could be induced by exogenous interleukin lαILl-α at concentrations ranging from 0. 01 to 20ng/ml during in vitro culture. Maximum expression was observed with 2-5ng/ml. In time-course experiments ICAM-1 was not expressed after 4h in culture with IL1α Expression was induced by 16h and was sustained for a minimum of 6 days in the continued presence of the cytokine. The endothelial leucocyte adhesion molecule (ELAM-1) was not expressed on chondrocytes and was not induced by IL1-α. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：207 / 216

页数：10

共 24 条

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