THE INVOLVEMENT OF INSULIN IN TRYPTAMINE-INDUCED HYPOGLYCEMIA IN MICE

被引：5
|
作者：
SUGIMOTO, Y
KIMURA, I
YAMADA, J
WATANABE, Y
TAKEUCHI, N
HORISAKA, K
机构：
[1] Department of Pharmacology Kobe Women's College of Pharmacy, Higashinada-Ku, Kobe, 658, Motoyamakita-Machi
来源：
LIFE SCIENCES | 1991年 / 48卷 / 17期
关键词：
D O I：
10.1016/0024-3205(91)90128-X
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of tryptamine on plasma glucose and serum insulin levels were studied in mice. Tryptamine elicited dose-dependent hypoglycemia and hyperinsulinemia in intact mice. In streptozotocin-diabetic mice, tryptamine did not change plasma glucose nor serum insulin levels. Tryptamine significantly inhibited glucose-induced hyperglycemia and enhanced insulin release elicited by glucose. These results indicate that tryptamine-induced hypoglycemia is brought on by its releasing effects of insulin.
引用
收藏
页码：1679 / 1683
页数：5
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