TETANUS TOXIN-INDUCED PROTEIN KINASE-C ACTIVATION AND ELEVATED SEROTONIN LEVELS IN THE PERINATAL RAT-BRAIN

被引：10
作者：
AGUILERA, J
LOPEZ, LA
YAVIN, E
机构：
[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL
[2] UNIV AUTONOMA BARCELONA,DEPT BIOCHEM & MOLEC BIOL,CERDANYOLA,SPAIN
来源：
FEBS LETTERS | 1990年 / 263卷 / 01期
关键词：
Brain development; Ganglioside; Protein kinase C; Serotonin; Tetanus toxin;
D O I：
10.1016/0014-5793(90)80705-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A single intracerebral injection of tetanus toxin (TeTox) is able to produce a time-dependent translocation of Ca2+-phosphatidylserine-dependent protein kinase C (PKC) in close-to-tenn rat brain. TeTox-triggered translocation of PKC is dose- and time-dependent, can be prevented by tetanus antitoxin, and does not occur upon administration of toxin fragments B and C. TeTox-triggered PKC translocation is accompanied by a timedependent increase in brain serotonin (5-HT). Increase of brain 5-HT is independent of monoamine oxidase inhibition by pargyline. Phorbol ester and TeTox cause a significant increase in serotonin while H-7, a kinase inhibitor, does not affect serotonin levels but abolishes the effect of TeTox. Gangliosides prevent TeTox-triggered 5-HT increase. The data are consistent with the possibility that TeTox acts effectively on the serotonergic innervation, presumably in conjunction with PKC to cause accumulation of serotonin. © 1990.
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页码：61 / 65
页数：5
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