MECHANISM OF BETA-ADRENERGIC RELAXATION OF SMOOTH-MUSCLE

被引：324

作者：

SCHEID, CR

HONEYMAN, TW

FAY, FS

机构：

[1] Department of Physiology, University of Massachusetts, Medical School, Worcester

来源：

NATURE | 1979年 / 277卷 / 5691期

关键词：

D O I：

10.1038/277032a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mechanism of β-adrenergic relaxation was investigated in isolated smooth muscle cells. β-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange. © 1979 Nature Publishing Group.

引用

页码：32 / 36

页数：5

共 56 条

[1]

Andersson R, 1975, Adv Cyclic Nucleotide Res, V5, P491

[2]

[Anonymous], 1971, CYCLIC AMP, DOI DOI 10.1146/ANNUREV.BI.37.070168.001053

[3]

BIRNBAUM JE, 1975, J PHARMACOL EXP THER, V194, P396

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