DISTRIBUTION OF NMDAR1 RECEPTOR SUBUNIT MESSENGER-RNA AND [I-125] MK-801 BINDING IN THE HYPOTHALAMUS OF INTACT, CASTRATE AND CASTRATE-DHTP TREATED MALE-RATS

被引：35

作者：

KUS, L ^{[1
]}

HANDA, RJ ^{[1
]}

SANDERSON, JJ ^{[1
]}

KERR, JE ^{[1
]}

BEITZ, AJ ^{[1
]}

机构：

[1] LOYOLA UNIV,DEPT ANAT CELL BIOL & NEUROBIOL,MAYWOOD,IL 60153

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 28卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

EXCITATORY AMINO ACID; HYPOTHALAMUS; ANDROGEN; GLUTAMATE; NMDA; NMDAR1; CASTRATION; MK-801; LATERAL SEPTUM; SUPRAOPTIC NUCLEUS; MESSENGER-RNA;

D O I：

10.1016/0169-328X(94)00179-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examines NMDAR1 receptor subunit mRNA expression and [I-125]MK-801 binding in hypothalamic and limbic nuclei of intact, castrate and castrate-dihydrotestosterone propionate (DHTP)-treated male rats. In intact rats, the highest levels of NMDAR1 mRNA were observed in the supraoptic, suprachiasmatic, ventromedial and arcuate nuclei. Low levels of hybridization were observed in the bed nucleus of the stria terminalis, lateral preoptic area, lateral hypothalamic area and lateral septum. In castrated rats both NMDAR1 mRNA and [I-125]MK-801 binding are significantly decreased in the lateral septum compared to castrate rats treated with DHTP, a non-aromatizable androgen. NMDAR1 mRNA was also significantly decreased in the supraoptic nucleus of castrate rats when compared to castrate rats treated with DHTP. These data suggest that androgens may modulate NMDA receptor function in some parts of the central nervous system.

引用

页码：55 / 60

页数：6

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