MECHANISMS OF THE PRESSOR-RESPONSE TO INTRAVENOUS THYROTROPIN-RELEASING-HORMONE IN THE RAT

被引：2

作者：

EVEQUOZ, D ^{[1
]}

BURNIER, M ^{[1
]}

NIEDERBERGER, M ^{[1
]}

BRUNNER, HR ^{[1
]}

NUSSBERGER, J ^{[1
]}

WAEBER, B ^{[1
]}

机构：

[1] CHU VAUDOIS, DIV HYPERTENS, CH-1011 LAUSANNE, SWITZERLAND

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1994年 / 21卷 / 02期

关键词：

BLOOD PRESSURE; HEART RATE; MEDULLECTOMY; SYMPATHETIC SYSTEM; THYROTROPIN-RELEASING HORMONE;

D O I：

10.1111/j.1440-1681.1994.tb02474.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The purpose of this study was to examine the contribution of the sympatho-adrenomedullary system to the blood pressure response to an intravenous bolus of thyrotropin-releasing hormone (TRH) in conscious medullectomized and sham-operated rats. 2. The peak presser effect of 0.5 mg TRH was significantly increased in rats having no adrenal medulla (+24.2+/-1.6 mmHg, mean+/-s.e.m., P<0.01) as compared to sham-operated animals (+12.2+/-3.0 mmHg).

引用

页码：93 / 100

页数：8

共 30 条

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