CYTOGENETIC TRICLONALITY IN ACUTE MYELOID-LEUKEMIA - A MORPHOLOGIC, IMMUNOLOGICAL AND IN-SITU HYBRIDIZATION STUDY

被引：15

作者：

KWONG, YL ^{[1
]}

LAM, CK ^{[1
]}

CHAN, AYY ^{[1
]}

LIE, AKW ^{[1
]}

CHAN, LC ^{[1
]}

机构：

[1] UNIV HONG KONG,QUEEN MARY HOSP,DEPT PATHOL,HONG KONG,HONG KONG

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 72卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)90120-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetically unrelated clones are uncommon in hematologic malignancies. We report a case of acute myeloid leukemia, which consisted morphologically of two populations of small and large blasts demonstrating immunophenotypic heterogeneity. Cytogenetic analysis showed 3 karyotypically abnormal clones: 47,XY,+14/45,XY,dic(5;17)(q11;p11),14dmin, and a near-tetraploid clone. In situ hybridization showed that the near-tetraploid clone corresponded to the large blasts, and the near-diploid clones the small blasts, therefore demonstrating a direct relationship between cell size and DNA content. The diverse morphologic, immunologic and cytogenetic heterogeneity observed in our case suggested hematopoietic oligoclonality.

引用

页码：86 / 91

页数：6

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