A HYPOTHESIS FOR CHEMICAL CARCINOGEN-INDUCED CHROMATIN CONDENSATION

被引：6
|
作者：
YU, FL
机构：
[1] Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, Rockford, IL 61107
来源：
CARCINOGENESIS | 1993年 / 14卷 / 09期
关键词：
D O I：
10.1093/carcin/14.9.1969
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A hypothesis for chemical carcinogen induced condensation of nuclear and nucleolar chromatin is proposed. Chromatin condensation is believed to be a result of cascade effects initiated by the inhibition of messenger RNA synthesis after exposure to chemical carcinogen in vivo. Inhibition of messenger RNA synthesis leads to the loss of protein production, which in turn causes the dephosphorylation of histone H1 and triggers the condensation of chromatin in vivo.
引用
收藏
页码：1969 / 1970
页数：2
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