ANTITUMORAL CYCLIC PEPTIDE ANALOGS OF CHLAMYDOCIN

被引：14

作者：

BERNARDI, E

FAUCHERE, JL

ATASSI, G

VIALLEFONT, P

LAZARO, R

机构：

[1] UNIV MONTPELLIER 2,AMINOACIDES & PEPTIDES LAB,CNRS,URA 468,PL E BATAILLON,F-34095 MONTPELLIER 05,FRANCE

[2] INST RECH SERVIER,F-92150 SURESNES,FRANCE

来源：

PEPTIDES | 1993年 / 14卷 / 06期

关键词：

CHLAMYDOCIN; ANTITUMORAL PEPTIDES; CYCLIC PEPTIDES;

D O I：

10.1016/0196-9781(93)90160-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of cyclic tetrapeptides bearing the bioactive alkylating group on an epsilon-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One analogue belonging to the chlamydocin family and bearing a beta-chloroethylnitrosourea group was found to be potent at inhibiting L1210 cell proliferation and had a higher therapeutic index than the reference compound bis-beta-chloroethylnitrosourea (BCNU) on the in vivo P388-induced leukemia model.

引用

页码：1091 / 1093

页数：3

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