EFFECTS OF ARGININE MODIFICATION OF NAJA-NIGRICOLLIS AND NAJA-NAJA-ATRA SNAKE-VENOM PHOSPHOLIPASES A2 ON ENZYMATIC-ACTIVITY, LETHALITY AND ANTICOAGULANT ACTION

被引：17

作者：

CONDREA, E ^{[1
]}

RAPUANO, BE ^{[1
]}

FLETCHER, JE ^{[1
]}

YANG, CC ^{[1
]}

ROSENBERG, P ^{[1
]}

机构：

[1] NATL TSINGHUA UNIV,INST MOLEC BIOL,HSINCHU,TAIWAN

来源：

TOXICON | 1981年 / 19卷 / 05期

关键词：

D O I：

10.1016/0041-0101(81)90109-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：721 / 725

页数：5

共 14 条

[1] COMPARISON OF A RELATIVELY TOXIC PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS SNAKE-VENOM WITH THAT OF A RELATIVELY NON-TOXIC PHOSPHOLIPASE-A2 FROM HEMACHATUS-HAEMACHATUS SNAKE-VENOM .1. ENZYMATIC-ACTIVITY ON FREE AND MEMBRANE-BOUND SUBSTRATES [J].

CONDREA, E ;

YANG, CC ;

ROSENBERG, P .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (11) :1555-1563

[2] EFFECT OF MODIFICATION OF ONE HISTIDINE RESIDUE ON THE ENZYMATIC AND PHARMACOLOGICAL PROPERTIES OF A TOXIC PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS SNAKE-VENOM AND LESS TOXIC PHOSPHOLIPASES-A2 FROM HEMACHATUS-HAEMACHATUS AND NAJA-NAJA-ATRA SNAKE-VENOMS [J].

CONDREA, E ;

FLETCHER, JE ;

RAPUANO, BE ;

YANG, CC ;

ROSENBERG, P .

TOXICON, 1981, 19 (01) :61-71

[3]

CONDREA E, 1981, THROMBOSIS HAEMOSTAS, V45, P820

[4]

CONDREA E, 1981, TOXICON, V19, P711

[5] COMPARISON OF A RELATIVELY TOXIC PHOSPHOLIPASE-A2 FROM NAJA-NIGRICOLLIS SNAKE-VENOM WITH THAT OF A RELATIVELY NON-TOXIC PHOSPHOLIPASE-A2 FROM HEMACHATUS-HAEMACHATUS SNAKE-VENOM .2. PHARMACOLOGICAL PROPERTIES IN RELATIONSHIP TO ENZYMATIC-ACTIVITY [J].

FLETCHER, JE ;

RAPUANO, BE ;

CONDREA, E ;

YANG, CC ;

RYAN, M ;

ROSENBERG, P .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (11) :1565-1574

[6]

FLETCHER JE, 1981, TOXICOL APPL PHARMAC

[7]

Gabriel, 1971, METHOD ENZYMOL, V22, P565, DOI 10.1016/0076-6879(71)22041-3

[8]

TAKAHASHI K, 1968, J BIOL CHEM, V243, P6171

[9]

TSAI IH, 1981, TOXICON, V19, P141

[10]

VENSEL LA, 1980, J BIOL CHEM, V255, P7306

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