DETECTION OF ACTIVE FORM OF TRANSFORMING GROWTH-FACTOR-BETA IN CEREBROSPINAL-FLUID OF PATIENTS WITH GLIOMA

被引：33

作者：

TADA, T ^{[1
]}

YABU, K ^{[1
]}

KOBAYASHI, S ^{[1
]}

机构：

[1] SHINSHU UNIV,SCH MED,DEPT INTERNAL MED 2,MATSUMOTO,NAGANO 390,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1993年 / 84卷 / 05期

关键词：

TGF-BETA; CEREBROSPINAL FLUID; GLIOMA; BRAIN TUMOR;

D O I：

10.1111/j.1349-7006.1993.tb00174.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined transforming growth factor-beta (TGF-beta) activity in cerebrospinal fluid of 39 patients with various brain tumors, and found it in 10 glioma cases that had lesions related to subarachnoid space or ventricle. In one glioma case, TGF-beta detected on admission disappeared after radiation and chemotherapy. We confirmed that five glioma cell lines produced TGF-beta, and that four of them produced active form of TGF-beta directly. The active form of TGF-beta was also identified from cerebrospinal fluid before the acidification treatment in two cases. The calculated contents were 110 ng/ml and 18 ng/ml. These results indicate that active form of TGF-beta is directly produced by tumor cells in patients with glioma, and may contribute to immunodeficiency of the host.

引用

页码：544 / 548

页数：5

共 14 条

[1]

BODMER S, 1989, J IMMUNOL, V143, P3222

[2] THE TRANSFORMING GROWTH-FACTOR-BETA SYSTEM, A COMPLEX PATTERN OF CROSS-REACTIVE LIGANDS AND RECEPTORS [J].

CHEIFETZ, S ;

WEATHERBEE, JA ;

TSANG, MLS ;

ANDERSON, JK ;

MOLE, JE ;

LUCAS, R ;

MASSAGUE, J .

CELL, 1987, 48 (03) :409-415

[3] IMMUNODETECTION AND QUANTITATION OF THE 2 FORMS OF TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA-1 AND TGF-BETA-2) SECRETED BY CELLS IN CULTURE [J].

DANIELPOUR, D ;

DART, LL ;

FLANDERS, KC ;

ROBERTS, AB ;

SPORN, MB .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (01) :79-86

[4]

DELARCO JE, 1978, P NATL ACAD SCI USA, V75, P4001

[5] COMPLEMENTARY-DNA FOR HUMAN GLIOBLASTOMA-DERIVED T-CELL SUPPRESSOR FACTOR, A NOVEL MEMBER OF THE TRANSFORMING GROWTH FACTO-BETA GENE FAMILY [J].

DEMARTIN, R ;

HAENDLER, B ;

HOFERWARBINEK, R ;

GAUGITSCH, H ;

WRANN, M ;

SCHLUSENER, H ;

SEIFERT, JM ;

BODMER, S ;

FONTANA, A ;

HOFER, E .

EMBO JOURNAL, 1987, 6 (12) :3673-3677

[6] THE TGF-BETA FAMILY OF GROWTH AND DIFFERENTIATION FACTORS [J].

MASSAGUE, J .

CELL, 1987, 49 (04) :437-438

[7] THE GROWTH INHIBITOR OF AFRICAN-GREEN MONKEY (BSC-1) CELLS IS TRANSFORMING GROWTH-FACTORS BETA-1 AND BETA-2 [J].

MCPHERSON, JM ;

SAWAMURA, SJ ;

OGAWA, Y ;

DINELEY, K ;

CARRILLO, P ;

PIEZ, KA .

BIOCHEMISTRY, 1989, 28 (08) :3442-3447

[8]

OCONNORMCCOURT MD, 1987, J BIOL CHEM, V262, P14090

[9] NEW CLASS OF TRANSFORMING GROWTH-FACTORS POTENTIATED BY EPIDERMAL GROWTH-FACTOR - ISOLATION FROM NON-NEOPLASTIC TISSUES [J].

ROBERTS, AB ;

ANZANO, MA ;

LAMB, LC ;

SMITH, JM ;

SPORN, MB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5339-5343

[10] ELEVATED LEVELS OF PLASMA TRANSFORMING GROWTH-FACTOR-BETA IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA [J].

SHIRAI, Y ;

KAWATA, S ;

ITO, N ;

TAMURA, S ;

TAKAISHI, K ;

KISO, S ;

TSUSHIMA, H ;

MATSUZAWA, Y .

JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (07) :676-679

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