Tumor necrosis factor-alpha concentrations in preeclamptic and healthy normotensive pregnant patients

被引：0
|
作者：
Reyna-Villasmil, E. [1 ]
Mejia-Montilla, J. [1 ]
Reyna-Villasmil, N. [1 ]
Torres-Cepeda, D. [1 ]
Santos-Bolivar, J. [1 ]
Perozo-Romero, J. [1 ]
机构：
[1] Hosp Cent Dr Urquinaona, Serv Obstet & Ginecol, Maternidad Dr Nerio Belloso, Maracaibo, Estado Zulia, Venezuela
来源：
CLINICA E INVESTIGACION EN GINECOLOGIA Y OBSTETRICIA | 2012年 / 39卷 / 06期
关键词：
Tumor necrosis factor alpha; Preeclampsia; Cytokines;
D O I：
10.1016/j.gine.2009.12.014
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To compare tumor necrosis factor-alpha concentrations in patients with preeclampsia and healthy normotensive pregnant women. Material And Methods: One hundred patients were selected. Fifty preeclamptic patients were selected as cases (group A) and 50 healthy pregnant women with a similar age and body mass index to patients in group A were selected as controls (group B). Blood samples for tumor necrosis factor-alpha determination were collected in all patients before labor and immediately after diagnosis in the study group. Results: There were no significant differences in maternal age, gestational age or body mass index at sample collection (p=ns). Statistically significant differences were found between groups in mean values of systolic and diastolic blood pressure (p<0.05). Significant differences were found in tumor necrosis factor-alpha concentrations in group A (9.7 +/- 4.6 pg/ml) and patients in group B ( 5.5 +/- 1.6 pg/ml; p<0.05), and a moderate, positive and significant correlation was found with mean systolic (r=0.433; p<0.05) and diastolic (r=0.412; p<0.05) blood pressure. Conclusions: Tumor necrosis factor-alpha concentrations were significantly higher in preeclamptic patients than in healthy normotensive pregnant women. (C) 2009 Elsevier Espana, S.L. All rights reserved.
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页码：236 / 240
页数：5
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