PRESYNAPTIC INHIBITORY EFFECT OF TNF-ALPHA ON THE RELEASE OF NORADRENALINE IN ISOLATED MEDIAN-EMINENCE

被引：62

作者：

ELENKOV, IJ

KOVACS, K

DUDA, E

STARK, E

VIZI, ES ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,INST EXPTL MED,POB 67,H-1450 BUDAPEST,HUNGARY

[2] BIOL RES CTR,INST BIOCHEM,H-6701 SZEGED,HUNGARY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 41卷 / 01期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; MEDIAN EMINENCE; NORADRENALINE RELEASE; PRESYNAPTIC MODULATION; NEUROIMMUNE COMMUNICATION;

D O I：

10.1016/0165-5728(92)90203-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system. Median eminence, loaded with [H-3]noradrenaline, was superfused with Krebs solution and stimulated electrically (2 Hz, 120 shocks). The effect of TNF-alpha was studied on the S2/S1 ratio. It was found that stimulation-evoked release of NA from noradrenergic axon terminals in the isolated rat ME was inhibited by TNF-alpha and this effect was concentration-dependent. In contrast, TNF-alpha had no effect on the release of [H-3]NA from the spleen. Since NA released in the ME might be involved in the modulation of corticotropin-releasing factor (CRF) production, it is suggested that TNF-alpha, through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME, might regulate CRF and other neurohormone release in this hypothalamic structure.

引用

页码：117 / 120

页数：4

共 24 条

[11] LIPOPOLYSACCHARIDE IS ABLE TO BYPASS CORTICOTROPIN-RELEASING FACTOR IN AFFECTING PLASMA ACTH AND CORTICOSTERONE LEVELS - EVIDENCE FROM RATS WITH LESIONS OF THE PARAVENTRICULAR NUCLEUS [J].