PRESYNAPTIC INHIBITORY EFFECT OF TNF-ALPHA ON THE RELEASE OF NORADRENALINE IN ISOLATED MEDIAN-EMINENCE

被引：62
作者：
ELENKOV, IJ
KOVACS, K
DUDA, E
STARK, E
VIZI, ES [1 ]
机构：
[1] HUNGARIAN ACAD SCI,INST EXPTL MED,POB 67,H-1450 BUDAPEST,HUNGARY
[2] BIOL RES CTR,INST BIOCHEM,H-6701 SZEGED,HUNGARY
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 41卷 / 01期
关键词：
TUMOR NECROSIS FACTOR-ALPHA; MEDIAN EMINENCE; NORADRENALINE RELEASE; PRESYNAPTIC MODULATION; NEUROIMMUNE COMMUNICATION;
D O I：
10.1016/0165-5728(92)90203-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system. Median eminence, loaded with [H-3]noradrenaline, was superfused with Krebs solution and stimulated electrically (2 Hz, 120 shocks). The effect of TNF-alpha was studied on the S2/S1 ratio. It was found that stimulation-evoked release of NA from noradrenergic axon terminals in the isolated rat ME was inhibited by TNF-alpha and this effect was concentration-dependent. In contrast, TNF-alpha had no effect on the release of [H-3]NA from the spleen. Since NA released in the ME might be involved in the modulation of corticotropin-releasing factor (CRF) production, it is suggested that TNF-alpha, through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME, might regulate CRF and other neurohormone release in this hypothalamic structure.
引用
收藏
页码：117 / 120
页数：4
相关论文
共 24 条
[1]   CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1 [J].
BERKENBOSCH, F ;
VANOERS, J ;
DELREY, A ;
TILDERS, F ;
BESEDOVSKY, H .
SCIENCE, 1987, 238 (4826) :524-526
[2]   INTERACTIONS BETWEEN TUMOR NECROSIS FACTOR-ALPHA, HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE, AND ADRENOCORTICOTROPIN SECRETION IN THE RAT [J].
BERNARDINI, R ;
KAMILARIS, TC ;
CALOGERO, AE ;
JOHNSON, EO ;
GOMEZ, MT ;
GOLD, PW ;
CHROUSOS, GP .
ENDOCRINOLOGY, 1990, 126 (06) :2876-2881
[3]   RELEASE OF MULTIPLE HORMONES BY A DIRECT ACTION OF INTERLEUKIN-1 ON PITUITARY-CELLS [J].
BERNTON, EW ;
BEACH, JE ;
HOLADAY, JW ;
SMALLRIDGE, RC ;
FEIN, HG .
SCIENCE, 1987, 238 (4826) :519-521
[4]   IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES [J].
BESEDOVSKY, H ;
DELREY, A ;
SORKIN, E ;
DINARELLO, CA .
SCIENCE, 1986, 233 (4764) :652-654
[5]   THE IMMUNE-RESPONSE EVOKES CHANGES IN BRAIN NORADRENERGIC NEURONS [J].
BESEDOVSKY, H ;
DELREY, A ;
SORKIN, E ;
DAPRADA, M ;
BURRI, R ;
HONEGGER, C .
SCIENCE, 1983, 221 (4610) :564-566
[6]   WHAT DO THE IMMUNE-SYSTEM AND THE BRAIN KNOW ABOUT EACH OTHER [J].
BESEDOVSKY, HO ;
DELREY, AE ;
SORKIN, E .
IMMUNOLOGY TODAY, 1983, 4 (12) :342-346
[7]   A MOLECULAR-BASIS FOR BIDIRECTIONAL COMMUNICATION BETWEEN THE IMMUNE AND NEURO-ENDOCRINE SYSTEMS [J].
BLALOCK, JE .
PHYSIOLOGICAL REVIEWS, 1989, 69 (01) :1-32
[8]   ACUTE CHANGES IN NOREPINEPHRINE CONTENT IN MEDIAN-EMINENCE INDUCED BY ORCHIDECTOMY OR TESTOSTERONE REPLACEMENT [J].
CHIOCCHIO, SR ;
NEGROVILAR, A ;
TRAMEZZANI, JH .
ENDOCRINOLOGY, 1976, 99 (02) :629-635
[9]   MODULATION OF CORTICOTROPHIN-RELEASING FACTOR RELEASE FROM HYPOTHALAMIC SYNAPTOSOMES [J].
EDWARDSON, JA ;
BENNETT, GW .
NATURE, 1974, 251 (5474) :425-427
[10]   PRESYNAPTIC MODULATION OF RELEASE OF NORADRENALINE FROM THE SYMPATHETIC-NERVE TERMINALS IN THE RAT SPLEEN [J].
ELENKOV, IJ ;
VIZI, ES .
NEUROPHARMACOLOGY, 1991, 30 (12A) :1319-1324
123