IDENTIFICATION AND PRELIMINARY CHARACTERIZATION OF A PROTEIN MOTIF RELATED TO THE ZINC FINGER

被引：319

作者：

LOVERING, R

HANSON, IM

BORDEN, KLB

MARTIN, S

OREILLY, NJ

EVAN, GI

RAHMAN, D

PAPPIN, DJC

TROWSDALE, J

FREEMONT, PS

机构：

[1] IMPERIAL CANC RES FUND, HUMAN IMMUNOGENET LAB, LONDON WC2A 3PX, ENGLAND

[2] IMPERIAL CANC RES FUND, PEPTIDE SYNTH LAB, LONDON WC2A 3PX, ENGLAND

[3] IMPERIAL CANC RES FUND, PROT SEQUENCING LAB, LONDON WC2A 3PX, ENGLAND

[4] IMPERIAL CANC RES FUND, PROT STRUCT LAB, LONDON WC2A 3PX, ENGLAND

[5] NATL INST MED RES, LONDON NW7 1AA, ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 06期

关键词：

DNA BINDING; SPECTROSCOPY; ZINC BINDING;

D O I：

10.1073/pnas.90.6.2112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six. We propose naming this motif the ''RING finger'' and it is found in 27 proteins, all of which have putative DNA binding functions. We have synthesized a peptide corresponding to the RING1 motif and examined a number of properties, including metal and DNA binding. We provide evidence to support the suggestion that the RING finger motif is the DNA binding domain of this newly defined family of proteins.

引用

页码：2112 / 2116

页数：5

共 64 条

[1] SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF CD2-GAL4 FROM SACCHAROMYCES-CEREVISIAE [J].