Syndrome of a systemic inflammatory reaction at the acute pancreatitis: peculiarities of a molecular pathophysiology and possible ways of correction

Aim of the given work is a study of the lornoxycam-cyclooxygenase inhibitor influence on the proinflammatory and antiinflammatory cytokine output, stipulated by ligands of the 1st and 2nd type Toll-like receptors (TLR1/2) and the 4th type Toll-like receptors (TLR4), the mononuclear cells of the healthy donor peripheral blood in vitro and in patients with the AP. Materials and methods. Influence of a nonsteroid antiinflammatory preparation on a synthesis of the pro- and and antiinflammatory cytokines was assessed in 10 healthy donors and 11 patients with the acute pancreatitis. Results. A release of the endogenous ligand significant concentrations takes place at the acute pancreatitis as a result of the organism proper cell large number death, which leads to activation of the TLR signal ways, activation of the immune system cell and starts the pro-inflammatory cytokine output. That fact necessitates the preparation with a cytokine-inhibiting activity inclusion into a complex therapy of AP.