ENANTIOSELECTIVE OXIDATION OF MANDELIC-ACID USING A PHENYLMALONATE METABOLIZING PATHWAY OF A SOIL BACTERIUM ALCALIGENES-BRONCHISEPTICUS KU1201

被引：25
作者：
MIYAMOTO, K [1 ]
OHTA, H [1 ]
机构：
[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,HIYOSHI 3-14-1,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN
来源：
BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 05期
关键词：
D O I：
10.1007/BF01021248
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The metabolic pathway of phenylmalonic acid by Alcaligenes bronchisepticus KU1201, which catalyzes the asymmetric decarboxylation of alpha-aryl-alpha-methylmalonic acids to alpha-arylpropionic acids, is demonstrated. Enantioselective oxidation of mandelic acid was investigated using the metabolizing pathway in this strain. Incubation of (+/-)-mandelic acid with A. bronchisepticus afforded optically pure (R)-one accompanied by benzoylformic acid and benzoic acid. This enzymatic oxidation is also applicable to various substituted mandelic acids.
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页码：363 / 366
页数：4
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