Eosinophilic Fasciitis Associated with Myositis

被引：6

作者：

Adachi, Yuko ^{[1
]}

Mizutani, Yoko ^{[1
]}

Shu, En ^{[1
]}

Kanoh, Hiroyuki ^{[1
]}

Miyazaki, Tatsuhiko ^{[2
]}

Seishima, Mariko ^{[1
]}

机构：

[1] Gifu Univ, Grad Sch Med, Dept Dermatol, 1-1 Yanagido, Gifu 5011194, Japan

[2] Gifu Univ Hosp, Div Pathol, Gifu, Japan

来源：

CASE REPORTS IN DERMATOLOGY | 2015年 / 7卷 / 01期

基金：

日本学术振兴会;

关键词：

Eosinophilic fasciitis; Exercise; Magnetic resonance imaging; Myositis;

D O I：

10.1159/000381845

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. Lymphocytic infiltration and degeneration of the underlying muscle are rarely observed. We report a 69-year-old Japanese woman who presented with multiple areas of glossy induration and painful peau d'orange-like lesions on the chest and four extremities. T2-weighted magnetic resonance imaging showed significant hyperintense thickening of the fascia of the lower extremities. Histopathological examination of a biopsy specimen from the induration showed marked fibrinoid degeneration of the fascia and the neighboring muscle with mixed cellular infiltration of lymphocytes and eosinophils. The predominant CD8+ lymphocytic infiltrates were observed by immunohistological study. A diagnosis of eosinophilic fasciitis with myositis was made. Oral administration of prednisolone and discontinuation of exercise significantly improved the lesions and pain. (C) 2015 S. Karger AG, Basel

引用

页码：79 / 83

页数：5

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