CHOLINERGIC MODULATION OF GROWTH-HORMONE SECRETION INDUCED BY GALANIN IN RATS

被引：10
作者：
TANOH, T
SHIMATSU, A
MURAKAMI, Y
ISHIKAWA, Y
YANAIHARA, N
IMURA, H
机构：
[1] KYOTO UNIV, FAC MED,DEPT INTERNAL MED,DIV 2, 5-4 SHOGOIN KAWAHARA CHO,SAKYO KU, KYOTO 606, JAPAN
[2] UNIV SHIZUOKA, SCH PHARMACEUT SCI, OYA, SHIZUOKA 422, JAPAN
来源：
NEUROENDOCRINOLOGY | 1991年 / 54卷 / 01期
关键词：
GALANIN; GROWTH HORMONE; HEXAMETHONIUM; TETRAETHYLAMMONIUM; PIRENZEPINE; NEOSTIGMINE; ANTISOMATOSTATIN ANTISERUM; SOMATOSTATIN;
D O I：
10.1159/000125855
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of cholinergic modulation by hexamethonium (HEX), tetraethylammonium (TEA), pirenzepine (PIR) and neostigmine on growth hormone (GH) secretion induced by galanin (GAL) were investigated in awake, freely moving male rats. Intracerebroventricular (i.c.v.) injection of GAL (0.6 nmol) caused a marked increase in plasma GH levels. Pretreatment with HEX (3 or 15 mg/kg BW), TEA (15 mg/kg BW) or PIR (0.5 mg/kg BW) significantly reduced the GAL-induced GH secretion. Pretreatment of animals with neostigmine (0.05 mg/kg BW) or with a specific antisomatostatin antiserum (10-mu-l of 1:10 diluted with saline, i.c.v.) reversed the inhibition of GAL-induced GH secretion by HEX. These findings suggest that both nicotinic and muscarinic cholinergic mechanisms interact with the galanin-induced GH secretion by modulating hypothalamic somatostatin release.
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页码：83 / 88
页数：6
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