SINGLE-COPY FLANKING SEQUENCES IN HUMAN HISTONE GENE CLUSTERS MAP TO CHROMOSOME-1 AND CHROMOSOME-6

被引：28
作者：
ALLEN, BS
STEIN, JL
STEIN, GS
OSTRER, H
机构：
[1] UNIV MASSACHUSETTS,DEPT CELL BIOL,WORCESTER,MA 01605
[2] UNIV FLORIDA,DEPT PEDIAT,RC PHILIPS RES & EDUC UNIT,GAINESVILLE,FL 32610
[3] UNIV FLORIDA,DEPT IMMUNOL & MED MICROBIOL,GAINESVILLE,FL 32610
来源：
GENOMICS | 1991年 / 10卷 / 02期
关键词：
D O I：
10.1016/0888-7543(91)90337-E
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two single-copy sequences flanking two different human histone gene clusters were used as probes to map these clusters by in situ hybridization. pFF435B, a unique sequence subclone derived from a lambda genomic clone (λHHG55) containing H2A, H2B, H3, and H4 genes, mapped to chromosome 1q21 (χ2 = 120.99, P < 0.001). pST519E, a single-copy sequence derived from a lambda genomic clone (λHHG17) containing only H3 and H4 genes, mapped to chromosome 6p21 (χ2 = 112.62, P < 0.001). These findings agree with previous assignments of human histone genes to chromosomes 1 and 6 and demonstrate that the single-copy flanking sequences in different human histone gene clusters are unique for different chromosomes. © 1991.
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收藏
页码：486 / 488
页数：3
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