MASS-SPECTRAL CHARACTERIZATION OF THE K-REGION AND NON K-REGION DIHYDRODIOLS OF 7,12-DIMETHYLBENZ(A)ANTHRACENE

被引：11

作者：

WONG, LK ^{[1
]}

WANG, CLA ^{[1
]}

DANIEL, FB ^{[1
]}

机构：

[1] OHIO STATE UNIV, COLL MED, DEPT RADIOL, COLUMBUS, OH 43210 USA

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 07期

关键词：

D O I：

10.1002/bms.1200060708

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Dihydrodiols are derived from intermediary arene oxides during the metabolism of polycyclic aromatic hydrocarbons. In this study, the mass spectra of the trimethylsilyl ether derivatives obtained from the 5,6‐dihydrodiol and 8,9‐dihydrodiol of 7,12‐dimethylbenz[a]anthracene were compared. The mass spectral fragmentation patterns indicate some key features in distinguishing a K‐region dihydrodiol from its non K‐region isomer. The 8,9‐dihydrodiol, a non K‐region metabolite, exhibits a greater tendency to undergo a ringcontraction fragmentation process while the K‐region 5,6‐dihydrodiol participates preferably in other fragmentation pathways. The data presented in this report will be useful in characterizing K‐region and non K‐region metabolic epoxidation of polycyclic aromatic hydrocarbons. Copyright © 1979 Heyden & Son Ltd

引用

页码：305 / 308

页数：4

共 15 条

[11] ELECTRONIC STRUCTURE AND CARCINOGENIC ACTIVITY OF AROMATIC MOLECULES - NEW DEVELOPMENTS
PULLMAN, A
PULLMAN, B
[J]. ADVANCES IN CANCER RESEARCH, 1955, 3 : 117 - 169
[12] Radford T., 1972, BIOCH APPLICATIONS M, P313
[13] IDENTIFICATION OF MAJOR ADDUCTS FORMED BY REACTION OF BENZO[A]PYRENE DIOL EPOXIDE WITH DNA INVITRO
STRAUB, KM
MEEHAN, T
BURLINGAME, AL
CALVIN, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5285 - 5289
[14] POLYCYCLIC HYDROCARBON EPOXIDES - INVOLVEMENT OF 8,9-DIHYDRO-8,9-DIHYDROXYBENZ (A) ANTHRACENE 10,11-OXIDE IN REACTIONS WITH DNA OF BENZ (A) ANTHRACENE-TREATED HAMSTER EMBRYO CELLS
SWAISLAND, AJ
HEWER, A
PAL, K
KEYSELL, GR
BOOTH, J
GROVER, PL
SIMS, P
[J]. FEBS LETTERS, 1974, 47 (01): : 34 - 38
[15] METABOLIC PATHWAYS OF 7,12-DIMETHYLBENZ[A]ANTHRACENE IN HEPATIC MICROSOMES
YANG, SK
DOWER, WV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (07) : 2601 - 2605

← 1 2 →