INVESTIGATION INTO SPECIES VARIANTS IN TACHYKININ NK1 RECEPTORS BY USE OF THE NONPEPTIDE ANTAGONIST, CP-96,345

被引：229
作者：
BERESFORD, IJM
BIRCH, PJ
HAGAN, RM
IRELAND, SJ
机构：
[1] Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, SG12 0DP, Park Road
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 104卷 / 02期
关键词：
TACHYKININ NK1 RECEPTOR; NK1 RECEPTOR ANTAGONIST; SPECIES VARIANTS; SUBTYPE, CP-96,345;
D O I：
10.1111/j.1476-5381.1991.tb12423.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.
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收藏
页码：292 / 293
页数：2
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