POLYMERIZATION OF LIPOSOMES EVALUATED FROM MOLECULAR-WEIGHT DISTRIBUTION OF DIENE-TYPE PHOSPHOLIPID POLYMERS

被引：8

作者：

TAKEOKA, S ^{[1
]}

KIMURA, N ^{[1
]}

OHNO, H ^{[1
]}

TSUCHIDA, E ^{[1
]}

机构：

[1] WASEDA UNIV,DEPT POLYMER CHEM,TOKYO 169,JAPAN

来源：

POLYMER JOURNAL | 1990年 / 22卷 / 10期

关键词：

Diene containing phospholipid; Liposomes; Molecular weight distribution; Uv-irradiation;

D O I：

10.1295/polymj.22.867

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

1, 2-Bis(2, 4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) or 1-palmitoyl-2-(2, 4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (POPC) was dispersed in water by sonication to form liposomes. DODPC liposomes were polymerized by UV-irradiation or with radical initiator such as azobis(2-amidinopropane)dihydrochloride (AAPD) at 60°C and methanolyzed to obtain THF-soluble polymers. The molecular weight distribution obtained from a gel permeation chromatography reveals that the UV-irradiation provides low-molecular-weight products and a small amount of polymers, while free radical polymerization gives polymers having relatively high-molecular-weight. The molecular weight of the phospholipid polymers is also influenced by the assembling state. The constrained lipid packing of small unilamellar POPC liposomes provides relatively low-molecular-weight polymers in comparison with those of larger liposomes. In addition, POPC liposomes polymerized at the temperature above the gel-to-liquid crystalline phase transition temperature (Tc) show the higher molecular weight of polymers than those polymerized below the Tc. © 1990 The Society of Polymer Science, Japan.

引用

页码：867 / 874

页数：8