DOSE-RESPONSE CHARACTERISTICS OF IMMUNOLOGICAL-UNRESPONSIVENESS TO UV-INDUCED TUMORS PRODUCED BY UV IRRADIATION OF MICE

被引：62

作者：

DEFABO, EC

KRIPKE, ML

机构：

[1] NCI,FREDERICK CANC RES CTR,PROGRAM CANC BIOL,FREDERICK,MD 21701

[2] US EPA,STRATOSPHER MODIFICAT RES STAFF,WASHINGTON,DC 20460

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1979年 / 30卷 / 03期

关键词：

D O I：

10.1111/j.1751-1097.1979.tb07372.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Irradiation of mice with unfiltered FS40 sunlamps renders them susceptible to challenge with highly antigenic UV‐induced skin tumors. Dose‐response studies demonstrated that the susceptibility of mice to tumor challenge was directly proportional to the total dose of UV radiation, and was independent of the manner in which the dose was administered. A fractionated dose was no more effective than the same total dose given as a single treatment in inducing susceptibility to tumor challenge. The effects of even suboptimal doses of UV radiation persisted for as long as 6 months after the UV treatment. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：385 / 390

页数：6

共 14 条

[1]

Blum H.F., 1959, CARCINOGENESIS ULTRA

[2] SYSTEMIC ALTERATION INDUCED IN MICE BY UV LIGHT IRRADIATION AND ITS RELATIONSHIP TO UV CARCINOGENESIS [J].