ANTI-CLOTTING PROPERTIES OF FRAGMENTS-D FROM HUMAN-FIBRINOGEN AND FIBRIN

被引：56

作者：

HAVERKATE, F

TIMAN, G

NIEUWENHUIZEN, W

机构：

[1] Gaubius Institute, Health Research Organization, TNO, Leiden

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 9卷 / 04期

关键词：

anti‐clotting; Ca[!sup]2+[!/sup] ions; Fibrin(ogen) fragment D;

D O I：

10.1111/j.1365-2362.1979.tb00881.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. It appeared from our previous studies that Ca2+ concentrations comparable to those occurring in blood protect the C‐terminal part of the γ‐chain remnants of fibrin(ogen) fragments D against further plasmin attack. This study shows that purified fibrin(ogen) fragments D formed in the presence of Ca2+ ions have anticlotting activity in vitro, whereas shortening of the γ‐chain remnants leads to loss of such activity. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：253 / 255

页数：3

共 17 条

[1] PATHOGENESIS OF COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (FIBRINOLYTIC) STATES .2. SIGNIFICANCE, MECHANISM AND CONSEQUENCES OF DEFECTIVE FIBRIN POLYMERIZATION [J].