METHOD DEVELOPMENT AND VALIDATION FOR THE ANALYSIS OF CAPECITABINE BY RP-HPLC METHOD

被引：0
|
作者：
Fathima, Azka [1 ]
Gazi, Shaik [1 ]
机构：
[1] Deccan Sch Pharm, Dept Pharmaceut Anal &QA, Hyderabad 500001, India
来源：
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 5卷 / 08期
关键词：
Capecitabine; RP-HPLC; validation;
D O I：
10.5281/zenodo.1402154
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Capecitabine, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6x150mm, 5 mu m) column using a mixture of Acetonitrile: Water (50:50v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 245 nm. The retention time of the Capecitabine was 2.4 +/- 0.02min. The method produce linear responses in the concentration range of 15-75mg/ml of Capecitabine. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
引用
收藏
页码：7808 / 7814
页数：7
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